Dr. Perlstein received his doctorate in Clinical Psychology from the University of Delaware (1994) and was a National Institutes of Health Postdoctoral Fellow at the University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA (1995 - 1998). He is currently an Associate Professor in the Department of Clinical and Health Psychology, with a joint appointment in the Department of Psychiatry. Dr. Perlstein directs the Clinical-Cognitive Neuroscience Laboratory, housed in the McKnight Brain Institute.

Research Focus

Dr. Perlstein’s research focuses on understanding the cognitive and neural mechanisms of normal (including aging) and abnormal (schizophrenia, anxiety and affective disorders, traumatic brain injury) information processing using theoretically-motivated cognitive tasks and indices of brain activity (functional magnetic resonance imaging, high-density electroencephalography/event-related potentials). This research draws from the theoretical spectrum of clinical and cognitive psychology and psychiatry to emotion neuroscience—i.e., clinical-cognitive neuroscience—and employs empirical methods from clinical and cognitive psychology, experimental neuropsychology, cognitive neuroscience and medical imaging.

Clinical Focus

Dr. Perlstein is a licensed Clinical Psychologist in the Department’s Psychology Clinic. The main focus of his applied work is in the area of differential diagnosis and treatment of adults with psychological disorders. His particular expertise is in the areas of anxiety, depressive, and psychotic disorders. Assessment approaches combine structured (e.g., SCID, ADIS) and semi-structured interview methods and, to a lesser extent, psychological testing. Treatment approaches draw primarily from cognitive-behavioral and interpersonal methods.


Experimental Methods in Neuropsychology and Cognitive Neuroscience

Representative publications

Price DD, Craggs J, Nicholas Verne G, Perlstein WM, Robinson ME (2006). Placebo analgesia is accompanied by large reductions in pain-related brain activity in irritable bowel syndrome patients. Pain, Sep 7;[Epub ahead of print]

Larson MJ, Perlstein WM, Demery JA, Stigge-Kaufman DA (2006). Cognitive control impairments in traumatic brain injury. J Clin Exp Neuropsychol, 28, 968-86.

Larson MJ, Perlstein WM, Stigge-Kaufman D, Kelly KG, Dotson VM (2006). Affective context-induced modulation of the error-related negativity. Neuroreport, 17, 329-33.

Seignourel PJ, Robins DL, Larson MJ, Demery JA, Cole M, Perlstein WM (2005). Cognitive control in closed head injury: context maintenance dysfunction or prepotent response inhibition deficit? Neuropsychology, 19, 578-90.

Perlstein WM, Larson MJ, Dotson VM, Kelly KG (2006). Temporal dissociation of components of cognitive control dysfunction in severe TBI: ERPs and the cued-Stroop task. Neuropsychologia, 44, 260-74.

Curriculum Vitae

Coming Soon